Journal article icon

Journal article

Structure of human factor VIIa and its implications for the triggering of blood coagulation.

Abstract:

Factor VIIa (EC 3.4.21.21) is a trypsin-like serine protease that plays a key role in the blood coagulation cascade. On injury, factor VIIa forms a complex with its allosteric regulator, tissue factor, and initiates blood clotting. Although the structure of the binary complex has already been determined [Banner, D. W., D'Arcy, A., Chène, C., Winkler, F. K., Guha, A., Konigsberg, W. H., Nemerson, Y. and Kirchhofer, D. (1996) Nature (London) 380, 41-46], the conformational effects of cofactor b...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1073/pnas.96.16.8925
Journal:
Proceedings of the National Academy of Sciences of the United States of America More from this journal
Volume:
96
Issue:
16
Pages:
8925-8930
Publication date:
1999-08-01
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
Language:
English
Keywords:
Pubs id:
pubs:317555
UUID:
uuid:f9707077-d9ab-48e7-b711-54b3eacecba8
Local pid:
pubs:317555
Source identifiers:
317555
Deposit date:
2012-12-19

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP