Journal article

Low testosterone and myasthenia gravis in males: a national record-linkage study

Abstract:: A disease of ‘young women and old men’, myasthenia gravis (MG) exhibits a bimodal distribution in age with a peak in the second and third decades of life with a female predominance, and a later peak in the sixth-to-eighth decades of life with a male predominance [1]. A role for low testosterone in influencing MG risk in males is suggested by the fact that the age-dependent risk of MG in males coincides with an age-related decline in male testosterone levels [2]. Exploration of a role of testosterone has previously been limited to one case report of hypergonadotropic hypogonadism and MG [3]. We aimed to investigate an association between testicular hypofunction (TH), as a proxy for low testosterone levels, and subsequent MG risk in males.

Publication status:: Published

Peer review status:: Peer reviewed

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APA Style

Pakpoor, J., Goldacre, R., & Goldacre, M. J. (2016). Low testosterone and myasthenia gravis in males: a national record-linkage study. Journal of Neurology, 263(12), 2547–2548.

MLA Style

Pakpoor, J., et al. “Low Testosterone and Myasthenia Gravis in Males: a National Record-Linkage Study.” Journal of Neurology, vol. 263, no. 12, Springer, 2016, pp. 2547–48.

Chicago Style

Pakpoor, J, R Goldacre, and MJ Goldacre. 2016. “Low Testosterone and Myasthenia Gravis in Males: a National Record-Linkage Study.” Journal of Neurology 263 (12): 2547–48.
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Files:: Low testosterone and myasthenia gravis in males - A national r...

(Preview, Accepted manuscript, pdf, 225.9KB, Terms of use)

Publisher copy:: 10.1007/s00415-016-8319-5

Authors

+ Pakpoor, J More by this author

Institution:: University of Oxford
Division:: Medical Sciences Division
Department:: Nuffield Dept of Population Health
Role:: Author

+ Goldacre, R More by this author

Institution:: University of Oxford
Division:: MSD
Department:: Nuffield Department of Population Health
Sub department:: Population Health
Role:: Author

+ Goldacre, MJ More by this author

Institution:: University of Oxford
Division:: Medical Sciences Division
Department:: Nuffield Department of Population Health
Sub department:: Population Health
Oxford college:: Magdalen College
Role:: Author

Publisher:: Springer
Journal:: Journal of Neurology More from this journal
Volume:: 263
Issue:: 12
Pages:: 2547-2548
Publication date:: 2016-10-24
Acceptance date:: 2016-10-16
DOI:: 10.1007/s00415-016-8319-5
EISSN:: 1432-1459
ISSN:: 0340-5354
Pmid:: 27778162

Language:: English
Keywords:: hemorrhoid

reference cohort

testicular diseases

cohort studies

hospital episode statistics

testosterone

Myasthenia gravis

gall bladder disease
Pubs id:: pubs:656969
UUID:: uuid:f966c691-f45d-4025-96c3-62ec58e3ae65
Local pid:: pubs:656969
Source identifiers:: 656969
Deposit date:: 2018-11-07

Terms of use

Copyright holder:: Springer-Verlag Berlin Heidelberg
Copyright date:: 2016
Notes:: © Springer-Verlag Berlin Heidelberg 2016. This is the accepted manuscript version of the article. The final version is available online from Springer at: https://doi.org/10.1007/s00415-016-8319-5

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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