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Activation of RAF/MEK/ERK and PI3K/AKT/mTOR pathways in pituitary adenomas and their effects on downstream effectors.

Abstract:

Raf/MEK/ERK and phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) cascades are key signalling pathways interacting with each other to regulate cell growth and tumourigenesis. We have previously shown B-Raf and Akt overexpression and/or overactivation in pituitary adenomas. The aim of this study is to assess the expression of their downstream components (MEK1/2, ERK1/2, mTOR, TSC2, p70S6K) and effectors (c-MYC and CYCLIN D1). We studied tissue from 16 non-functionin...

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Publication status:
Published

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Publisher copy:
10.1677/erc-09-0101

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Journal:
Endocrine-related cancer More from this journal
Volume:
16
Issue:
4
Pages:
1329-1338
Publication date:
2009-12-01
DOI:
EISSN:
1479-6821
ISSN:
1351-0088

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