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Journal article

A large-scale association analysis of common variation of the HNF1alpha gene with type 2 diabetes in the U.K. Caucasian population.

Abstract:

HNF1alpha (TCF1) is a key transcription factor that is essential for pancreatic beta-cell development and function. Rare mutations of HNF1alpha cause maturity-onset diabetes of the young. A common variant, G319S, private to the Oji-Cree population, predisposes to type 2 diabetes, but the role of common HNF1alpha variation in European populations has not been comprehensively assessed. We determined the linkage disequilibrium and haplotype structure across the HNF1alpha gene region using 29 sin...

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Publication status:
Published

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Publisher copy:
10.2337/diabetes.54.8.2487

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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, OCDEM
Role:
Author
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Journal:
Diabetes
Volume:
54
Issue:
8
Pages:
2487-2491
Publication date:
2005-08-05
DOI:
EISSN:
1939-327X
ISSN:
0012-1797
URN:
uuid:f92f5e37-5f81-4b06-b564-ca29da6aba38
Source identifiers:
14647
Local pid:
pubs:14647

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