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Recent developments in using mechanistic cardiac modelling for drug safety evaluation

Abstract:

On the tenth anniversary of two key International Conference on Harmonisation (ICH) guidelines relating to cardiac proarrhythmic safety, an initiative aims to consider the implementation of a new paradigm that combines in vitro and in silico technologies to improve risk assessment. The Comprehensive In Vitro Proarrhythmia Assay (CiPA) initiative (co-sponsored by the Cardiac Safety Research Consortium, Health and Environmental Sciences Institute, Safety Pharmacology Society and FDA) is a bold ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
MPLS
Department:
Computer Science
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
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Name:
Wellcome Trust
Grant:
Open Access funding
Publisher:
Elsevier
Journal:
Drug Discovery Today More from this journal
Publication date:
2016-02-15
Acceptance date:
2016-02-01
DOI:
EISSN:
1878-5832
ISSN:
1359-6446
Pubs id:
pubs:605750
UUID:
uuid:f91b5a26-ef32-4c92-9154-aa81425b5d5c
Local pid:
pubs:605750
Source identifiers:
605750
Deposit date:
2016-02-23

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