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Journal article

Structure and molecular mechanism of a nucleobase-cation-symport-1 family transporter.

Abstract:

The nucleobase-cation-symport-1 (NCS1) transporters are essential components of salvage pathways for nucleobases and related metabolites. Here, we report the 2.85-angstrom resolution structure of the NCS1 benzyl-hydantoin transporter, Mhp1, from Microbacterium liquefaciens. Mhp1 contains 12 transmembrane helices, 10 of which are arranged in two inverted repeats of five helices. The structures of the outward-facing open and substrate-bound occluded conformations were solved, showing how the ou...

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Publication status:
Published

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Publisher copy:
10.1126/science.1164440

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Journal:
Science (New York, N.Y.) More from this journal
Volume:
322
Issue:
5902
Pages:
709-713
Publication date:
2008-10-01
DOI:
EISSN:
1095-9203
ISSN:
0036-8075
Language:
English
Keywords:
Pubs id:
pubs:72813
UUID:
uuid:f91aa8fd-4ce6-4e24-979b-023858ac0ee0
Local pid:
pubs:72813
Source identifiers:
72813
Deposit date:
2012-12-19

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