Spatio-temporal organization of network activity patterns in the hippocampus

Journal article

Understanding how coordinated neural networks support brain functions remains a central goal in neuroscience. The hippocampus, with its layered architecture and structured inputs to diverse cell populations, is a tractable model for dissecting operating microcircuits through the analysis of electrophysiological signatures. We investigated hippocampal network patterns in behaving mice by developing a low-dimensional embedding of local field potentials recorded along the CA1-to-dentate gyrus axis. This embedding revealed layer-specific gamma profiles reflecting spatially organized rhythms and their associated principal cell-interneuron firing motifs. Moreover, firing behaviors along the CA1 radial axis distinguished between deep and superficial principal cells, as well as between interneurons from the pyramidal, radiatum, and lacunosum-moleculare layers. These findings provide a comprehensive map of spatiotemporal activity patterns underlying hippocampal network functions.

Authors: Lopes-dos-Santos, V; Brizee, D; Dupret, D

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: Cell Press
• Journal: Cell Reports
• Volume: 44
• Issue: 6
• Article number: 115808
• Publication date: 2025-06-04
• Acceptance date: 2025-05-19
• DOI: 10.1016/j.celrep.2025.115808
• EISSN: 2211-1247
• ISSN: 2639-1856
• Language: English
• Keywords: hippocampus; network activity; neuronal populations; oscillations; firing motifs