Journal article : Review
Vascular smooth muscle cell dysfunction in neurodegeneration
- Abstract:
- Vascular smooth muscle cells (VSMCs) are the key moderators of cerebrovascular dynamics in response to the brain’s oxygen and nutrient demands. Crucially, VSMCs may provide a sensitive biomarker for neurodegenerative pathologies where vasculature is compromised. An increasing body of research suggests that VSMCs have remarkable plasticity and their pathophysiology may play a key role in the complex process of neurodegeneration. Furthermore, extrinsic risk factors, including environmental conditions and traumatic events can impact vascular function through changes in VSMC morphology. VSMC dysfunction can be characterised at the molecular level both preclinically, and clinically ex vivo. However the identification of VSMC dysfunction in living individuals is important to understand changes in vascular function at the onset and progression of neurological disorders such as dementia, Alzheimer’s disease, and Parkinson’s disease. A promising technique to identify changes in the state of cerebral smooth muscle is cerebrovascular reactivity (CVR) which reflects the intrinsic dynamic response of blood vessels in the brain to vasoactive stimuli in order to modulate regional cerebral blood flow (CBF). In this work, we review the role of VSMCs in the most common neurodegenerative disorders and identify physiological systems that may contribute to VSMC dysfunction. The evidence collected here identifies VSMC dysfunction as a strong candidate for novel therapeutics to combat the development and progression of neurodegeneration, and highlights the need for more research on the role of VSMCs and cerebrovascular dynamics in healthy and diseased states.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 1.1MB, Terms of use)
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- Publisher copy:
- 10.3389/fnins.2022.1010164
Authors
- Publisher:
- Frontiers Media
- Journal:
- Frontiers in Neuroscience More from this journal
- Volume:
- 16
- Article number:
- 1010164
- Publication date:
- 2022-11-10
- Acceptance date:
- 2022-10-24
- DOI:
- EISSN:
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1662-453X
- ISSN:
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1662-4548
- Pmid:
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36440263
- Language:
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English
- Keywords:
- Subtype:
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Review
- Pubs id:
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1312447
- Local pid:
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pubs:1312447
- Deposit date:
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2022-12-12
- ARK identifier:
Terms of use
- Copyright holder:
- Hayes et al.
- Copyright date:
- 2022
- Rights statement:
- Copyright © 2022 Hayes, Pinto, Sparks, Wang, Suri and Bulte. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
- Notes:
- This work is related to the thesis Models and methods of cerebrovascular reactivity mapping.
- Licence:
- CC Attribution (CC BY)
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