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Rapid and Sensitive Multiplex Detection of Burkholderia pseudomallei-Specific Antibodies in Melioidosis Patients Based on a Protein Microarray Approach.

Abstract:

The environmental bacterium Burkholderia pseudomallei causes the infectious disease melioidosis with a high case-fatality rate in tropical and subtropical regions. Direct pathogen detection can be difficult, and therefore an indirect serological test which might aid early diagnosis is desirable. However, current tests for antibodies against B. pseudomallei, including the reference indirect haemagglutination assay (IHA), lack sensitivity, specificity and standardization. Consequently, serologi...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pntd.0004847

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Department:
Oxford, MSD, NDM, Tropical Medicine
Müller, E More by this author
Jenjaroen, K More by this author
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Funding agency for:
Dunachie, SJ
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS Neglected Tropical Diseases Journal website
Issue:
7
Publication date:
2016-07-18
Acceptance date:
2016-06-22
DOI:
ISSN:
1935-2727 and 1935-2735
Pubs id:
pubs:636532
URN:
uri:f908becd-2a76-45c0-9138-d41dfbce924c
UUID:
uuid:f908becd-2a76-45c0-9138-d41dfbce924c
Local pid:
pubs:636532
Language:
English
Keywords:

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