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Rapid and Sensitive Multiplex Detection of Burkholderia pseudomallei-Specific Antibodies in Melioidosis Patients Based on a Protein Microarray Approach.

Abstract:

The environmental bacterium Burkholderia pseudomallei causes the infectious disease melioidosis with a high case-fatality rate in tropical and subtropical regions. Direct pathogen detection can be difficult, and therefore an indirect serological test which might aid early diagnosis is desirable. However, current tests for antibodies against B. pseudomallei, including the reference indirect haemagglutination assay (IHA), lack sensitivity, specificity and standardization. Consequently, serologi...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Tropical Medicine
Role:
Author
More from this funder
Name:
Wellcome Trust
Funding agency for:
Dunachie, S
Grant:
WT100174/Z/12/Z
Publisher:
Public Library of Science
Journal:
PLoS Neglected Tropical Diseases More from this journal
Issue:
7
Publication date:
2016-07-18
Acceptance date:
2016-06-22
DOI:
ISSN:
1935-2735 and 1935-2727
Pmid:
27427979
Language:
English
Keywords:
Pubs id:
pubs:636532
UUID:
uuid:f908becd-2a76-45c0-9138-d41dfbce924c
Local pid:
pubs:636532
Source identifiers:
636532
Deposit date:
2016-09-16

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