Journal article
Measured and genetically predicted protein levels and cardiovascular diseases in UK Biobank and China Kadoorie Biobank
- Abstract:
- Several large-scale studies have measured plasma levels of the proteome in individuals with cardiovascular diseases (CVDs). However, since the majority of such proteins are interrelated, it is difficult for observational studies to distinguish which proteins are likely to be of etiological relevance. Here we evaluate whether plasma levels of 2,919 proteins measured in 52,164 UK Biobank participants are associated with incident myocardial infarction, ischemic stroke or heart failure. Of those proteins, 126 were associated with all three CVD outcomes and 118 were associated with at least one CVD in the China Kadoorie Biobank. Mendelian randomization and colocalization analyses indicated that genetically determined levels of 47 and 18 proteins, respectively, were associated with CVDs, including FGF5, PROCR and FURIN. While the majority of protein–CVD observational associations were noncausal, these three proteins showed evidence to support potential causality and are therefore promising targets for drug treatment for CVD outcomes.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 3.5MB, Terms of use)
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- Publisher copy:
- 10.1038/s44161-024-00545-6
Authors
- Publisher:
- Springer Nature
- Journal:
- Nature Cardiovascular Research More from this journal
- Volume:
- 3
- Issue:
- 10
- Pages:
- 1189–1198
- Place of publication:
- England
- Publication date:
- 2024-09-25
- Acceptance date:
- 2024-08-28
- DOI:
- EISSN:
-
2731-0590
- Pmid:
-
39322770
- Language:
-
English
- Keywords:
- Pubs id:
-
2033081
- Local pid:
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pubs:2033081
- Deposit date:
-
2024-10-02
Terms of use
- Copyright holder:
- Lind et al.
- Copyright date:
- 2024
- Rights statement:
- © The Author(s) 2024. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons. org/licenses/by/4.0/.
- Licence:
- CC Attribution (CC BY)
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