Journal article

Molecular and structural aspects of xenobiotic carbonyl metabolizing enzymes. Role of reductases and dehydrogenases in xenobiotic phase I reactions.

Abstract:: The major metabolic pathways involved in synthesis and disposition of carbonyl and hydroxyl group containing compounds are presented, and structural and functional characteristics of the enzyme families involved are discussed. Alcohol and aldehyde dehydrogenases (ADH, ALDH) participate in oxidative pathways, whereas reductive routes are accomplished by members of the aldo-keto reductase (AKR), short-chain dehydrogenases/reductases (SDR) and quinone reductase (QR) superfamilies. A wealth of biochemical, genetic and structural data now establishes these families to constitute important phase I enzymes.

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APA Style

Oppermann, U., & Maser, E. (2000). Molecular and structural aspects of xenobiotic carbonyl metabolizing enzymes. Role of reductases and dehydrogenases in xenobiotic phase I reactions. Toxicology, 144(1-3), 71–81.

MLA Style

Oppermann, U, and E Maser. “Molecular and Structural Aspects of Xenobiotic Carbonyl Metabolizing Enzymes. Role of Reductases and Dehydrogenases in Xenobiotic Phase I Reactions.” Toxicology, vol. 144, nos. 1-3, 2000, pp. 71–81.

Chicago Style

Oppermann, U, and E Maser. 2000. “Molecular and Structural Aspects of Xenobiotic Carbonyl Metabolizing Enzymes. Role of Reductases and Dehydrogenases in Xenobiotic Phase I Reactions.” Toxicology 144 (1-3): 71–81.
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Publisher copy:: 10.1016/s0300-483x(99)00192-4

Authors

+ Oppermann, U More by this author

Role:: Author

+ Maser, E More by this author

Role:: Author

Journal:: Toxicology More from this journal
Volume:: 144
Issue:: 1-3
Pages:: 71-81
Publication date:: 2000-04-01
DOI:: 10.1016/s0300-483x(99)00192-4
EISSN:: 1879-3185
ISSN:: 0300-483X

Language:: English
Keywords:: Xenobiotics

Protein Conformation

Humans

Animals

Oxidoreductases
Pubs id:: pubs:108890
UUID:: uuid:f902208c-f50c-43ed-8d64-683c315a4e59
Local pid:: pubs:108890
Source identifiers:: 108890
Deposit date:: 2012-12-19
ARK identifier:: ark:/29072/ora_f902208cf50c43ed8d64683c315a4e59

Terms of use

Copyright date:: 2000

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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