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TDP-43 expression in mouse models of amyotrophic lateral sclerosis and spinal muscular atrophy

Abstract:

Background: Redistribution of nuclear TAR DNA binding protein 43 (TDP-43) to the cytoplasm and ubiquitinated inclusions of spinal motor neurons and glial cells is characteristic of amyotrophic lateral sclerosis (ALS) pathology. Recent evidence suggests that TDP-43 pathology is common to sporadic ALS and familial ALS without SOD1 mutation, but not SOD1-related fALS cases. Furthermore, it remains unclear whether TDP-43 abnormalities occur in non-ALS forms...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1186/1471-2202-9-104

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Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
Publisher:
BioMed Central
Journal:
BMC Neuroscience More from this journal
Volume:
9
Article number:
104
Publication date:
2008-10-28
Acceptance date:
2008-10-28
DOI:
EISSN:
1471-2202
Language:
English
Keywords:
Pubs id:
pubs:240945
UUID:
uuid:f8fbc96c-21e0-4a12-85df-1388c2474287
Local pid:
pubs:240945
Source identifiers:
240945
Deposit date:
2012-12-19

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