3' non-coding region sequences in eukaryotic messenger RNA.

Journal article

The sequence A-A-U-A-A-A is present in six different purified messenger RNA molecules (specifically the alpha-and beta-globulin mRNAs of rabbit and human, the immunoglobulin light chain mRNA of mouse (MOPC 21) and the ovalbumin mRNA of chicken) about 20 residues away from the 3'-terminal poly (A) sequence. In addition, a large selection of the 3' non-coding regions of rabbit and human globulin mRNAs (both the alpha and beta globin mRNAs) are 85% homologous, demonstrating that this region is significantly conserved in evolution.

Authors: Proudfoot, N; Brownlee, G

• Publication status: Published
• Journal: Nature
• Volume: 263
• Issue: 5574
• Pages: 211-214
• Publication date: 1976-09-01
• DOI: 10.1038/263211a0
• EISSN: 1476-4687
• ISSN: 0028-0836
• Language: English
• Keywords: Immunoglobulin Light Chains; Animals; Ovalbumin; Base Sequence; Myeloma Proteins; Rabbits; Poly A; Species Specificity; Humans; Mice; Biological Evolution; Globins; Chickens; RNA, Messenger