Biophysical models applied to dementia patients reveal links between geographical origin, gender, disease duration, and loss of neural inhibition

Moguilner, S; Herzog, R; Perl, YS; Medel, V; Cruzat, J; Coronel, C; Kringelbach, M; Deco, G; Ibáñez, A; Tagliazucchi, E

Journal article

Biophysical models applied to dementia patients reveal links between geographical origin, gender, disease duration, and loss of neural inhibition

Abstract:: Fil: Ibanez, Agustin. Trinity College; Irlanda.Fil: Moguilner, Sebastian. Harvard Medical School; United States.Fil: Baez, Sandra. Universidad de los Andes; Colombia.Fil: Barttfeld, Pablo. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina.Fil: Barttfeld, Pablo. Consejo Nacional de Investigaciones Científicas y Tecnológicas. Instituto de Investigaciones Psicológicas; Argentina.Brain clocks, which quantify discrepancies between brain age and chronological age, hold promise for understanding brain health and disease. However, the impact of multimodal diversity (geographical, socioeconomic, sociodemographic, sex, neurodegeneration) on the brain age gap (BAG) is unknown. Here, we analyzed datasets from 5,306 participants across 15 countries (7 Latin American countries -LAC, 8 non-LAC). Based on higher-order interactions in brain signals, we developed a BAG deep learning architecture for functional magnetic resonance imaging (fMRI=2,953) and electroencephalography (EEG=2,353). The datasets comprised healthy controls, and individuals with mild cognitive impairment, Alzheimer’s disease, and behavioral variant frontotemporal dementia. LAC models evidenced older brain ages (fMRI: MDE=5.60, RMSE=11.91; EEG: MDE=5.34, RMSE=9.82) compared to non-LAC, associated with frontoposterior networks. Structural socioeconomic inequality and other disparity-related factors (pollution, health disparities) were influential predictors of increased brain age gaps, especially in LAC (R²=0.37, F²=0.59, RMSE=6.9). A gradient of increasing BAG from controls to mild cognitive impairment to Alzheimer’s disease was found. In LAC, we observed larger BAGs in females in control and Alzheimer’s disease groups compared to respective males. Results were not explained by variations in signal quality, demographics, or acquisition methods. Findings provide a quantitative framework capturing the multimodal diversity of accelerated brain aging.info:eu-repo/semantics/acceptedVersionFil: Ibanez, Agustin. Trinity College; Irlanda.Fil: Moguilner, Sebastian. Harvard Medical School; United States.Fil: Baez, Sandra. Universidad de los Andes; Colombia.Fil: Barttfeld, Pablo. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina.Fil: Barttfeld, Pablo. Consejo Nacional de Investigaciones Científicas y Tecnológicas. Instituto de Investigaciones Psicológicas; Argentina

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Peer review status:: Peer reviewed

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APA Style

Moguilner, S., Herzog, R., Perl, Y. S., Medel, V., Cruzat, J., Coronel, C., Kringelbach, M., Deco, G., Ibáñez, A., & Tagliazucchi, E. (2024). Biophysical models applied to dementia patients reveal links between geographical origin, gender, disease duration, and loss of neural inhibition. Alzheimer's Research & Therapy, 16(1), 79–79.

MLA Style

Moguilner, S, et al. “Biophysical Models Applied to Dementia Patients Reveal Links between Geographical Origin, Gender, Disease Duration, and Loss of Neural Inhibition.” Alzheimer's Research & Therapy, vol. 16, no. 1, 2024, pp. 79–79.

Chicago Style

Moguilner, S, R Herzog, YS Perl, et al. 2024. “Biophysical Models Applied to Dementia Patients Reveal Links between Geographical Origin, Gender, Disease Duration, and Loss of Neural Inhibition.” Alzheimer's Research & Therapy 16 (1): 79–79.
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