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Effect of acute tyrosine depletion in using a branched chain amino-acid mixture on dopamine neurotransmission in the rat brain.

Abstract:

Central dopamine function is reduced by decreasing the availability of the catecholamine precursor, tyrosine, using a tyrosine-free amino acid mixture containing multiple large neutral as well as branched chain amino-acids, which compete with tyrosine for uptake into the brain. Current mixtures are cumbersome to make and administer, and unpalatable to patients and volunteers. Here, we investigate whether individual or limited amino-acid combinations could reduce brain tyrosine levels and henc...

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Publication status:
Published

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Publisher copy:
10.1038/sj.npp.1300835

Authors


Le Masurier, M More by this author
Oldenzeil, W More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Psychiatry
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology
Journal:
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
Volume:
31
Issue:
2
Pages:
310-317
Publication date:
2006-02-05
DOI:
EISSN:
1740-634X
ISSN:
0893-133X
URN:
uuid:f8e5594b-9418-412e-9340-fe9a7680f2ec
Source identifiers:
139421
Local pid:
pubs:139421

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