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Whole-genome sequencing for predicting clarithromycin resistance in Mycobacterium abscessus

Abstract:

Mycobacterium abscessus is emerging as an important pathogen in chronic lung diseases, with concern regarding patient-to-patient transmission. The recent introduction of routine whole-genome sequencing (WGS) as a replacement for existing reference techniques in England provides an opportunity to characterize the genetic determinants of resistance. We conducted a systematic review to catalogue all known resistance-determining mutations. This knowledge was used to construct a predictive algorit...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1128/aac.01204-18

Authors


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Role:
Author
ORCID:
0000-0001-5872-9214
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Name:
Department of Health
Grant:
CL-2015-13-003
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Name:
National Institute for Health Research
Grant:
CL-2015-13-003
Publisher:
American Society for Microbiology
Journal:
Antimicrobial Agents and Chemotherapy More from this journal
Volume:
63
Issue:
1
Article number:
e01204-18
Publication date:
2018-11-05
Acceptance date:
2018-10-25
DOI:
EISSN:
1098-6596
ISSN:
0066-4804
Pmid:
30397069
Language:
English
Keywords:
Pubs id:
pubs:943792
UUID:
uuid:f8d98c34-431c-420c-8409-96bcfa6e1c52
Local pid:
pubs:943792
Source identifiers:
943792
Deposit date:
2019-06-05

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