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The immunological synapse

Abstract:

The immunological synapse (IS) is a stable cell-cell junction between a thymus-derived lymphocyte (T cell) and an antigen-presenting cell (APC). The IS concept provides a number of insights into the T cell activation process. Firstly, it provides a stop signal that coordinates antigen recognition and T cell migration. Secondly, the essential role of the actin cytoskeleton in T cell activation is related to the role of actin in IS formation. Third, the sensitivity of T cell to agonist MHCp is ...

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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Author
Publisher:
Elsevier
Volume:
1
Pages:
71-75
Publication date:
2010-01-01
DOI:
Language:
English
Pubs id:
pubs:426325
UUID:
uuid:f8ce76a0-0ca5-4487-a314-e269f8221090
Local pid:
pubs:426325
Source identifiers:
426325
Deposit date:
2014-07-10

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