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Journal article

Crystal structure of Spa40, the specificity switch for the Shigella flexneri type III secretion system.

Abstract:

The pathogenic bacterium Shigella flexneri uses a type III secretion system to inject virulence factors from the bacterial cytosol directly into host cells. The machinery that identifies secretion substrates and controls the export of extracellular components and effector proteins consists of several inner-membrane and cytoplasmic proteins. One of the inner membrane components, Spa40, belongs to a family of proteins proposed to regulate the switching of substrate specificity of the export app...

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Publication status:
Published

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Authors


Graham, SC More by this author
Mitchell, EP More by this author
Johnson, S More by this author
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Journal:
Molecular microbiology
Volume:
69
Issue:
1
Pages:
267-276
Publication date:
2008-07-05
DOI:
EISSN:
1365-2958
ISSN:
0950-382X
URN:
uuid:f8cd9e87-2a9d-4c09-9c2b-a58d828dec9d
Source identifiers:
4877
Local pid:
pubs:4877

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