Journal article

High-resolution analysis of cis-acting regulatory networks at the α-globin locus.

Abstract:: We have combined the circular chromosome conformation capture protocol with high-throughput, genome-wide sequence analysis to characterize the cis-acting regulatory network at a single locus. In contrast to methods which identify large interacting regions (10-1000 kb), the 4C approach provides a comprehensive, high-resolution analysis of a specific locus with the aim of defining, in detail, the cis-regulatory elements controlling a single gene or gene cluster. Using the human α-globin locus as a model, we detected all known local and long-range interactions with this gene cluster. In addition, we identified two interactions with genes located 300 kb (NME4) and 625 kb (FAM173a) from the α-globin cluster.

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APA Style

Hughes, J., Lower, K., Dunham, I., Taylor, S., De Gobbi, M., Sloane-Stanley, J., McGowan, S., Ragoussis, J., Vernimmen, D., Gibbons, R., & Higgs, D. (2013). High-resolution analysis of cis-acting regulatory networks at the α-globin locus. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences, 368(1620), 20120361–20120361.

MLA Style

Hughes, J, et al. “High-Resolution Analysis of Cis-Acting Regulatory Networks at the α-Globin Locus.” Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences, vol. 368, no. 1620, 2013, pp. 20120361–61.

Chicago Style

Hughes, J, K Lower, I Dunham, et al. 2013. “High-Resolution Analysis of Cis-Acting Regulatory Networks at the α-Globin Locus.” Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences 368 (1620): 20120361–61.
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Authors

+ Hughes, J More by this author

Institution:: University of Oxford
Division:: MSD
Department:: RDM
Sub department:: Weatherall Insti. of Molecular Medicine
Role:: Author

+ Lower, K More by this author

Role:: Author

+ Dunham, I More by this author

Role:: Author

+ Taylor, S More by this author

Role:: Author

+ De Gobbi, M More by this author

Role:: Author

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Journal:: Philosophical transactions of the Royal Society of London. Series B, Biological sciences More from this journal
Volume:: 368
Issue:: 1620
Pages:: 20120361-20120361
Publication date:: 2013-01-01
EISSN:: 1471-2970

Language:: English
Pubs id:: pubs:446042
UUID:: uuid:f8c93188-c24d-4280-9875-413026abdcbd
Local pid:: pubs:446042
Source identifiers:: 446042
Deposit date:: 2014-02-07
ARK identifier:: ark:/29072/ora_f8c93188c24d42809875413026abdcbd

Terms of use

Copyright date:: 2013

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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