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Deciphering the Mechanisms of Developmental Disorders (DMDD): a new programme for phenotyping embryonic lethal mice.

Abstract:

International efforts to test gene function in the mouse by the systematic knockout of each gene are creating many lines in which embryonic development is compromised. These homozygous lethal mutants represent a potential treasure trove for the biomedical community. Developmental biologists could exploit them in their studies of tissue differentiation and organogenesis; for clinical researchers they offer a powerful resource for investigating the origins of developmental diseases that affect ...

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Publication status:
Published

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Publisher copy:
10.1242/dmm.011957

Authors


Baldock, R More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Cardiovascular Medicine, BHF Centre of Research Excellence
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Journal:
Disease models and mechanisms
Volume:
6
Issue:
3
Pages:
562-566
Publication date:
2013-05-05
DOI:
EISSN:
1754-8411
ISSN:
1754-8403
URN:
uuid:f8bfc6f8-7bc5-4c31-a3ad-b63418964d41
Source identifiers:
405759
Local pid:
pubs:405759

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