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Influence of pH on Ca²⁺ current and its control of electrical and Ca²⁺ signaling in ventricular myocytes.

Abstract:

Modulation of L-type Ca(2+) current (I(Ca,L)) by H(+) ions in cardiac myocytes is controversial, with widely discrepant responses reported. The pH sensitivity of I(Ca,L) was investigated (whole cell voltage clamp) while measuring intracellular Ca(2+) (Ca(2+)(i)) or pH(i) (epifluorescence microscopy) in rabbit and guinea pig ventricular myocytes. Selectively reducing extracellular or intracellular pH (pH(o) 6.5 and pH(i) 6.7) had opposite effects on I(Ca,L) gating, shifting the steady-state ac...

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Publication status:
Published

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Publisher copy:
10.1085/jgp.201110658

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
Journal:
Journal of general physiology More from this journal
Volume:
138
Issue:
5
Pages:
537-559
Publication date:
2011-11-01
DOI:
EISSN:
1540-7748
ISSN:
0022-1295
Language:
English
Keywords:
Pubs id:
pubs:198759
UUID:
uuid:f8be6ac5-1b5b-4eec-9105-9ec6b639e843
Local pid:
pubs:198759
Source identifiers:
198759
Deposit date:
2012-12-19

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