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Identification of H5N1-specific T-cell responses in a high-risk cohort in vietnam indicates the existence of potential asymptomatic infections.

Abstract:

BACKGROUND: Most reported human H5N1 viral infections have been severe and were detected after hospital admission. A case ascertainment bias may therefore exist, with mild cases or asymptomatic infections going undetected. We sought evidence of mild or asymptomatic H5N1 infection by examining H5N1-specific T-cell and antibody responses in a high-risk cohort in Vietnam. METHODS: Peripheral blood mononuclear cells were tested using interferon-γ enzyme-linked immunospot T assays measuring the re...

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Publication status:
Published

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Publisher copy:
10.1093/infdis/jir689

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Journal:
The Journal of infectious diseases
Volume:
205
Issue:
1
Pages:
20-27
Publication date:
2012-01-05
DOI:
EISSN:
1537-6613
ISSN:
0022-1899
URN:
uuid:f8b0d6e0-86b1-4e16-a8ec-d9f85f9574b1
Source identifiers:
206077
Local pid:
pubs:206077

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