Journal article icon

Journal article

Structural basis and specificity of human otubain 1-mediated deubiquitination.

Abstract:

OTUB (otubain) 1 is a human deubiquitinating enzyme that is implicated in mediating lymphocyte antigen responsiveness, but whose molecular function is generally not well defined. A structural analysis of OTUB1 shows differences in accessibility to the active site and in surface properties of the substrate-binding regions when compared with its close homologue, OTUB2, suggesting variations in regulatory mechanisms and substrate specificity. Biochemical analysis reveals that OTUB1 has a prefere...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1042/bj20081318

Authors


Journal:
Biochemical journal More from this journal
Volume:
418
Issue:
2
Pages:
379-390
Publication date:
2009-03-01
DOI:
EISSN:
1470-8728
ISSN:
0264-6021

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP