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Journal article

Co-delivery of PLGA encapsulated invariant NKT cell agonist with antigenic protein induce strong T cell-mediated antitumor immune responses

Abstract:

Antitumor immunity can be enhanced by the coordinated release and delivery of antigens and immune-stimulating agents to antigen-presenting cells via biodegradable vaccine carriers. So far, encapsulation of TLR ligands and tumor-associated antigens augmented cytotoxic T cell (CTLs) responses. Here, we compared the efficacy of the invariant NKT (iNKT) cell agonist α-galactosylceramide (α-GalCer) and TLR ligands (R848 and poly I:C) as an adjuvant for the full length ovalbumin (OVA) in PLGA nanop...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1080/2162402X.2015.1068493

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Publisher:
Taylor & Francis Group Publisher's website
Journal:
Oncoimmunology Journal website
Volume:
5
Issue:
1
Pages:
e1068493
Chapter number:
ARTN e1068493
Publication date:
2015-08-12
Acceptance date:
2015-06-27
DOI:
EISSN:
2162-402X
ISSN:
2162-4011
URN:
uuid:f8834c73-8357-4245-b3b1-fb37bf61d2f0
Source identifiers:
598738
Local pid:
pubs:598738
Paper number:
1
Language:
English
Keywords:

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