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The role of adiposity in cardiometabolic traits: a Mendelian randomization analysis.

Abstract:

BACKGROUND: The association between adiposity and cardiometabolic traits is well known from epidemiological studies. Whilst the causal relationship is clear for some of these traits, for others it is not. We aimed to determine whether adiposity is causally related to various cardiometabolic traits using the Mendelian randomization approach. METHODS AND FINDINGS: We used the adiposity-associated variant rs9939609 at the FTO locus as an instrumental variable (IV) for body mass index (BMI) in a ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pmed.1001474

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Institution:
University of Oxford
Fischer, K More by this author
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European Network for Genetic and Genomic Epidemiology More from this funder
Avera Research Institute More from this funder
Biotechnology and Biological Sciences Research Council More from this funder
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Publisher:
Public Library of Science Publisher's website
Journal:
PLoS medicine Journal website
Volume:
10
Issue:
6
Pages:
Article: e1001474
Publication date:
2013
DOI:
EISSN:
1549-1676
ISSN:
1549-1277
URN:
uuid:f882d720-5b6d-49fa-a463-dae14338ecbf
Source identifiers:
410176
Local pid:
pubs:410176

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