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The role of adiposity in cardiometabolic traits: a Mendelian randomization analysis.

Abstract:

BACKGROUND: The association between adiposity and cardiometabolic traits is well known from epidemiological studies. Whilst the causal relationship is clear for some of these traits, for others it is not. We aimed to determine whether adiposity is causally related to various cardiometabolic traits using the Mendelian randomization approach. METHODS AND FINDINGS: We used the adiposity-associated variant rs9939609 at the FTO locus as an instrumental variable (IV) for body mass index (BMI) in a ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pmed.1001474

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Institution:
University of Oxford
Role:
Author
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Name:
American National Institutes of Health
Grant:
N01-RC-45035
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Name:
Netherlands Bioinformatics Centre
Grant:
2008.024
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Name:
Health Administration of Regione Lombardia
Grant:
17155/2004
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Name:
German National Genome Research Network
Grant:
01GS0834
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Name:
French Institute of Health and Medical Research
Grant:
U258
Publisher:
Public Library of Science
Journal:
PLoS medicine More from this journal
Volume:
10
Issue:
6
Article number:
e1001474
Publication date:
2013-01-01
DOI:
EISSN:
1549-1676
ISSN:
1549-1277

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