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Dose-related effects of selective 5-HT2 receptor antagonists on slow wave sleep in humans.

Abstract:

The effects of the selective 5-HT2 receptor antagonists, ritanserin (1, 5 and 10 mg) and ICI 169.369 (50 and 100 mg), were studied on the sleep EEG of healthy volunteers using home-based Medilog 9000 cassette monitoring. Ritanserin (5 and 10 mg) produced a significant increase in slow wave sleep (SWS) while ICI 169,369 also increased SWS but only at a dose of 100 mg. These findings are consistent with the proposal that selective 5-HT2 receptor blockade increases SWS in humans; however, the da...

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Publication status:
Published

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Publisher copy:
10.1007/bf02244239
Journal:
Psychopharmacology More from this journal
Volume:
101
Issue:
4
Pages:
568-569
Publication date:
1990-01-01
DOI:
EISSN:
1432-2072
ISSN:
0033-3158
Language:
English
Keywords:
Pubs id:
pubs:185825
UUID:
uuid:f8745eb9-0f9b-4aca-a935-0bb935d7bae8
Local pid:
pubs:185825
Source identifiers:
185825
Deposit date:
2012-12-19

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