Dose-related effects of selective 5-HT2 receptor antagonists on slow wave sleep in humans.

Journal article

The effects of the selective 5-HT2 receptor antagonists, ritanserin (1, 5 and 10 mg) and ICI 169.369 (50 and 100 mg), were studied on the sleep EEG of healthy volunteers using home-based Medilog 9000 cassette monitoring. Ritanserin (5 and 10 mg) produced a significant increase in slow wave sleep (SWS) while ICI 169,369 also increased SWS but only at a dose of 100 mg. These findings are consistent with the proposal that selective 5-HT2 receptor blockade increases SWS in humans; however, the data cannot exclude involvement of the closely related 5-HT1c receptor in this effect.

Authors: Sharpley, A; Solomon, R; Fernando, A; da Roza Davis, J; Cowen, P

• Publication status: Published
• Journal: Psychopharmacology
• Volume: 101
• Issue: 4
• Pages: 568-569
• Publication date: 1990-01-01
• DOI: 10.1007/bf02244239
• EISSN: 1432-2072
• ISSN: 0033-3158
• Language: English
• Keywords: Sleep; Humans; Receptors, Serotonin; Adult; Piperidines; Female; Serotonin Antagonists; Ritanserin; Electroencephalography; Male; Quinolines; Dose-Response Relationship, Drug