Exposure-response relationships in asthma caused by tetrachlorophthalic anhydride.

Journal article

Four patients with asthma caused by occupational exposure to tetrachlorophthalic anhydride (TCPA) had dust-challenge tests that used eight different levels of TCPA exposure. Measurements of TCPA in the test-cubicle air ranged from 1.3 to 961.1 micrograms/m3. The higher exposures provoked definite late or dual asthmatic responses. Smaller, but statistically significant, responses were observed at low exposures. The late asthmatic-response area had a linear relation to the logarithm of TCPA exposure, but the immediate asthmatic response was less closely related to exposure.

Authors: Venables, K; Newman Taylor, A

• Journal: Journal of allergy and clinical immunology
• Volume: 85
• Issue: 1 Pt 1
• Pages: 55-58
• Publication date: 1990-01-01
• DOI: 10.1016/0091-6749(90)90221-o
• EISSN: 1097-6825
• ISSN: 0091-6749
• Language: English
• Keywords: Dose-Response Relationship, Drug; Asthma; Adult; Phthalic Anhydrides; Histamine; Phthalic Acids; Forced Expiratory Volume; Occupational Diseases; Humans; Air Pollutants, Occupational; Dust; Middle Aged; Skin Tests; Bronchial Provocation Tests; Female