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Excessive production of interleukin 6/B cell stimulatory factor-2 in rheumatoid arthritis.

Abstract:

High levels of interleukin 6 (IL 6/B cell stimulatory factor-2) were detected in synovial fluids from the joints of patients with active rheumatoid arthritis (RA). The cells found in freshly isolated synovial fluid constitutively expressed IL 6 mRNA. The synovial tissues obtained by joint biopsy were also found to produce IL 6 in vitro. Immunohistochemical analysis demonstrated that CD2+ T cells as well as CD20+ blastoid B cells in the synovial tissues produce IL 6. The data indicate that IL ...

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Publisher copy:
10.1002/eji.1830181122

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Journal:
European journal of immunology
Volume:
18
Issue:
11
Pages:
1797-1801
Publication date:
1988-11-05
DOI:
EISSN:
1521-4141
ISSN:
0014-2980
URN:
uuid:f868eb19-b0f6-400a-b311-72c24d259408
Source identifiers:
482215
Local pid:
pubs:482215

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