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Recognition and kinetics for excision of a base lesion within clustered DNA damage by the Escherichia coli proteins Fpg and Nth.

Abstract:

Ionizing radiation and radiomimetic anticancer agents induce clustered DNA damages that are thought to lead to deleterious biological consequences, due to the challenge that clustered damage may present to the repair machinery of the cell. Specific oligonucleotides, containing either dihydrothymine (DHT) or 7,8-dihydro-8-oxoguanine (8-oxoG) opposite to specific lesions at defined positions on the complementary strand, have been used to determine the kinetic constants, K(M), k(cat), and specif...

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Publication status:
Published

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Publisher copy:
10.1021/bi002605d

Authors


David-Cordonnier, MH More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
Journal:
Biochemistry
Volume:
40
Issue:
19
Pages:
5738-5746
Publication date:
2001-05-05
DOI:
EISSN:
1520-4995
ISSN:
0006-2960
URN:
uuid:f8597a8f-6eb8-40f1-8eb5-0e5a48e2e919
Source identifiers:
131258
Local pid:
pubs:131258

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