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Journal article

Recognition and kinetics for excision of a base lesion within clustered DNA damage by the Escherichia coli proteins Fpg and Nth.

Abstract:

Ionizing radiation and radiomimetic anticancer agents induce clustered DNA damages that are thought to lead to deleterious biological consequences, due to the challenge that clustered damage may present to the repair machinery of the cell. Specific oligonucleotides, containing either dihydrothymine (DHT) or 7,8-dihydro-8-oxoguanine (8-oxoG) opposite to specific lesions at defined positions on the complementary strand, have been used to determine the kinetic constants, K(M), k(cat), and specif...

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Publication status:
Published

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Publisher copy:
10.1021/bi002605d

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
Journal:
Biochemistry More from this journal
Volume:
40
Issue:
19
Pages:
5738-5746
Publication date:
2001-05-01
DOI:
EISSN:
1520-4995
ISSN:
0006-2960
Language:
English
Keywords:
Pubs id:
pubs:131258
UUID:
uuid:f8597a8f-6eb8-40f1-8eb5-0e5a48e2e919
Local pid:
pubs:131258
Source identifiers:
131258
Deposit date:
2012-12-19

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