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Journal article

Structural features underlying T-cell receptor sensitivity to concealed MHC class I micropolymorphisms.

Abstract:

Polymorphic differences distinguishing MHC class I subtypes often permit the presentation of shared epitopes in conformationally identical formats but can affect T-cell repertoire selection, differentially impacting autoimmune susceptibilities and viral clearance in vivo. The molecular mechanisms underlying this effect are not well understood. We performed structural, thermodynamic, and functional analyses of a conserved T-cell receptor (TCR) which is frequently expanded in response to a HIV-...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.1207896109

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
Journal:
Proceedings of the National Academy of Sciences of the United States of America More from this journal
Volume:
109
Issue:
50
Pages:
E3483-E3492
Publication date:
2012-12-01
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
Language:
English
Keywords:
Pubs id:
pubs:363769
UUID:
uuid:f858520d-5a28-408a-a639-e0169991b8b5
Local pid:
pubs:363769
Source identifiers:
363769
Deposit date:
2013-11-17

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