Journal article icon

Journal article

MAIT cells: new guardians of the liver

Abstract:

The liver is an important immunological organ that remains sterile and tolerogenic in homeostasis, despite continual exposure to non-self food and microbial-derived products from the gut. However, where intestinal mucosal defenses are breached or in the presence of a systemic infection, the liver acts as a second 'firewall', because of its enrichment with innate effector cells able to rapidly respond to infections or tissue dysregulation. One of the largest populations of T cells within the h...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1038/cti.2016.51

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
More from this funder
Name:
National Institute of Health
Grant:
U19AI082630
More from this funder
Name:
Medical Research Council
Grant:
Stratified Medicine Award STOP-HCV
More from this funder
Name:
Wellcome Trust
Grant:
WT109965MA
More from this funder
Name:
National Institute of Health Research
Publisher:
Nature Publishing Group
Journal:
Clinical & translational immunology More from this journal
Volume:
5
Issue:
8
Pages:
e98
Publication date:
2016-08-19
Acceptance date:
2016-07-15
DOI:
EISSN:
2050-0068
Pmid:
27588203
Language:
English
Keywords:
Pubs id:
pubs:641848
UUID:
uuid:f85123c0-f18f-4936-a0f9-4bcb38f0f979
Local pid:
pubs:641848
Source identifiers:
641848
Deposit date:
2016-09-21

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP