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Journal article

MAIT cells: new guardians of the liver

Abstract:

The liver is an important immunological organ that remains sterile and tolerogenic in homeostasis, despite continual exposure to non-self food and microbial-derived products from the gut. However, where intestinal mucosal defenses are breached or in the presence of a systemic infection, the liver acts as a second 'firewall', because of its enrichment with innate effector cells able to rapidly respond to infections or tissue dysregulation. One of the largest populations of T cells within the h...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/cti.2016.51

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
More from this funder
Grant:
Stratified Medicine Award STOP-HCV
National Institute of Health Research More from this funder
Oxford Martin School More from this funder
Publisher:
Nature Publishing Group Publisher's website
Journal:
Clinical & translational immunology Journal website
Volume:
5
Issue:
8
Pages:
e98
Publication date:
2016-08-19
Acceptance date:
2016-07-15
DOI:
EISSN:
2050-0068
Pmid:
27588203
Source identifiers:
641848
Language:
English
Keywords:
Pubs id:
pubs:641848
UUID:
uuid:f85123c0-f18f-4936-a0f9-4bcb38f0f979
Local pid:
pubs:641848
Deposit date:
2016-09-21

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