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Journal article

Differential sensitivity of beta-cell and extrapancreatic K(ATP) channels to gliclazide.

Abstract:

AIMS/HYPOTHESIS: To investigate the tissue specificity of gliclazide for cloned beta-cell, cardiac and smooth muscle ATP-sensitive K-channels (K(ATP) channels). These channels share a common pore-forming subunit, Kir6.2, which associates with different sulphonylurea receptor isoforms (SUR1 in beta-cells, SUR2A in heart, SUR2B in smooth muscle). METHODS: Kir6.2 was coexpressed with SUR1, SUR2A or SUR2B in Xenopus oocytes, and channel activity was measured by recording macroscopic currents in g...

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Publication status:
Published

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Publisher copy:
10.1007/s001250051236

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
Journal:
Diabetologia More from this journal
Volume:
42
Issue:
7
Pages:
845-848
Publication date:
1999-07-01
DOI:
EISSN:
1432-0428
ISSN:
0012-186X
Language:
English
Keywords:
Pubs id:
pubs:114131
UUID:
uuid:f844051a-008a-4b3e-9c23-e26211f4b9cc
Local pid:
pubs:114131
Source identifiers:
114131
Deposit date:
2012-12-19

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