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Long-term retention of ECM hydrogel after implantation into a sub-acute stroke cavity reduces lesion volume

Abstract:

Salvaging or functional replacement of damaged tissue caused by stroke in the brain remains a major therapeutic challenge. In situ gelation and retention of a hydrogel bioscaffold composed of 8. mg/mL extracellular matrix (ECM) can induce a robust invasion of cells within 24. h and potentially promote a structural remodeling to replace lost tissue. Herein, we demonstrate a long-term retention of ECM hydrogel within the lesion cavity. A decrease of approximately 32% of ECM volume is observed o...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.actbio.2017.09.011

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Psychiatry
Role:
Author
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Name:
National Institute of Neurological Disorders and Stroke
Grant:
R01NS082226
Publisher:
Elsevier
Journal:
Acta Biomaterialia More from this journal
Volume:
63
Pages:
50-63
Publication date:
2017-09-13
Acceptance date:
2017-09-11
DOI:
ISSN:
1742-7061
Keywords:
Pubs id:
pubs:736972
UUID:
uuid:f83d4481-e68f-431c-9d3c-ccb9b675bc1c
Local pid:
pubs:736972
Source identifiers:
736972
Deposit date:
2017-10-18

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