Journal article
The impacts of SARS-CoV-2 vaccine dose separation and targeting on the COVID-19 epidemic in England
- Abstract:
- In late 2020, the JCVI (the Joint Committee on Vaccination and Immunisation, which provides advice to the Department of Health and Social Care, England) made two important recommendations for the initial roll-out of the COVID-19 vaccine. The first was that vaccines should be targeted to older and vulnerable people, with the aim of maximally preventing disease rather than infection. The second was to increase the interval between first and second doses from 3 to 12 weeks. Here, we re-examine these recommendations through a mathematical model of SARS-CoV-2 infection in England. We show that targeting the most vulnerable had the biggest immediate impact (compared to targeting younger individuals who may be more responsible for transmission). The 12-week delay was also highly beneficial, estimated to have averted between 32-72 thousand hospital admissions and 4-9 thousand deaths over the first ten months of the campaign (December 2020-September 2021) depending on the assumed interaction between dose interval and efficacy.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 1.4MB, Terms of use)
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(Preview, Supplementary materials, pdf, 3.0MB, Terms of use)
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- Publisher copy:
- 10.1038/s41467-023-35943-0
Authors
+ Medical Research Council
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- Funder identifier:
- https://ror.org/03x94j517
- Grant:
- MR/V009761/1
- MR/V038613/1
+ UK Research and Innovation
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- Funder identifier:
- https://ror.org/001aqnf71
- Grant:
- MR/V038613/1
+ National Institute for Health and Care Research
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- Funder identifier:
- https://ror.org/0187kwz08
- Grant:
- NIHR200411
+ Biotechnology and Biological Sciences Research Council
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- Funder identifier:
- https://ror.org/00cwqg982
- Grant:
- BB/S01750X/1
- Publisher:
- Springer Nature
- Journal:
- Nature Communications More from this journal
- Volume:
- 14
- Issue:
- 1
- Article number:
- 740
- Place of publication:
- England
- Publication date:
- 2023-02-10
- Acceptance date:
- 2023-01-09
- DOI:
- EISSN:
-
2041-1723
- Pmid:
-
36765050
- Language:
-
English
- Pubs id:
-
2033591
- Local pid:
-
pubs:2033591
- Source identifiers:
-
W4319924164
- Deposit date:
-
2026-04-28
- ARK identifier:
Terms of use
- Copyright holder:
- Keeling et al.
- Copyright date:
- 2023
- Rights statement:
- © The Author(s) 2023. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.
- Licence:
- CC Attribution (CC BY)
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