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Catalytic enantioselective synthesis of atropisomeric biaryls by a cation-directed O-alkylation

Abstract:

Axially chiral biaryls, as exemplified by 1,1’-bi-2-naphthol (BINOL), are key components of catalysts, natural products and medicines. These materials are synthesized conventionally in enantioenriched form through metal- mediated cross coupling, de novo construction of an aromatic ring, point-to-axial chirality transfer or an atropselective transformation of an existing biaryl. Here, we report a highly enantioselective organocatalytic method for the synthesis of atropisomeric biaryls by a cat...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1038/nchem.2710

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Department:
Oxford, MPLS, Chemistry, Organic Chemistry
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Department:
Oxford, MPLS, Chemistry, Organic Chemistry
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Department:
University College
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Grant:
(FP7/2007-2013) / ERC grant agreement no. 259056
Publisher:
Nature Publishing Group Publisher's website
Journal:
Nature Chemistry Journal website
Volume:
9
Pages:
558-562
Publication date:
2017-01-23
Acceptance date:
2016-11-30
DOI:
EISSN:
1755-4349
ISSN:
1755-4330
Pubs id:
pubs:664195
URN:
uri:f827863c-7f89-4ee5-a9c9-9f8f5dfc42b4
UUID:
uuid:f827863c-7f89-4ee5-a9c9-9f8f5dfc42b4
Local pid:
pubs:664195

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