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Preventing antimalarial drug resistance through combinations.

Abstract:

Throughout the tropical world antimalarial drug resistance is increasing, particularly in the potentially lethal malaria parasite Plasmodium falciparum. In some parts of Southeast Asia, parasites which are resistant to chloroquine, pyrimethamine-sulfadoxine, and mefloquine are prevalent. The characteristics of a drug that make it vulnerable to the development of resistance are a long terminal elimination half-life, a shallow concentration-effect relationship, and that one or two base-pair mut...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Role:
Author
Journal:
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy More from this journal
Volume:
1
Issue:
1
Pages:
3-9
Publication date:
1998-03-01
DOI:
EISSN:
1532-2084
ISSN:
1368-7646
Language:
English
Pubs id:
pubs:36724
UUID:
uuid:f8126e73-57fe-465b-8c47-edb415b5204d
Local pid:
pubs:36724
Source identifiers:
36724
Deposit date:
2012-12-19

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