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Erythrocyte-binding antigens of Plasmodium falciparum are targets of human inhibitory antibodies and function to evade naturally acquired immunity.

Abstract:

Abs that inhibit Plasmodium falciparum invasion of erythrocytes form an important component of human immunity against malaria, but key target Ags are largely unknown. Phenotypic variation by P. falciparum mediates the evasion of inhibitory Abs, contributing to the capacity of P. falciparum to cause repeat and chronic infections. However, Ags involved in mediating immune evasion have not been defined, and studies of the function of human Abs are limited. In this study, we used novel approaches...

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Publication status:
Published

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Publisher copy:
10.4049/jimmunol.1300444

Authors


Journal:
Journal of Immunology More from this journal
Volume:
191
Issue:
2
Pages:
785-794
Publication date:
2013-07-01
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
Language:
English
Keywords:
Pubs id:
pubs:415692
UUID:
uuid:f80cce73-db0f-48c6-a76e-cb3650a0b6e7
Local pid:
pubs:415692
Source identifiers:
415692
Deposit date:
2013-11-17

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