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Tryptophan depletion in normal volunteers produces selective impairments in learning and memory.

Abstract:

The amino-acid L-tryptophan is essential in the synthesis of brain serotonin, and its depletion can lead to a widespread reduction in central serotonergic activity. A placebo-controlled cross-over within-subjects design (n = 12) examined the effects of tryptophan depletion on human cognitive performance. A low-tryptophan (low-TRP) drink successfully reduced the levels of plasma and total free tryptophan. Computerized tests of memory, learning and executive function revealed selective and non-...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, RDM - Investigative Medicine Division
Sahakian, BJ More by this author
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Journal:
Neuropharmacology
Volume:
33
Issue:
3-4
Pages:
575-588
Publication date:
1994-03-05
DOI:
EISSN:
1873-7064
ISSN:
0028-3908
URN:
uuid:f80a2f5f-8b8c-4fc3-a631-f13a6da1a6e5
Source identifiers:
112359
Local pid:
pubs:112359

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