- Abstract:
-
The amino-acid L-tryptophan is essential in the synthesis of brain serotonin, and its depletion can lead to a widespread reduction in central serotonergic activity. A placebo-controlled cross-over within-subjects design (n = 12) examined the effects of tryptophan depletion on human cognitive performance. A low-tryptophan (low-TRP) drink successfully reduced the levels of plasma and total free tryptophan. Computerized tests of memory, learning and executive function revealed selective and non-...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1016/0028-3908(94)90089-2
-
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- Journal:
- Neuropharmacology
- Volume:
- 33
- Issue:
- 3-4
- Pages:
- 575-588
- Publication date:
- 1994-03-05
- DOI:
- EISSN:
-
1873-7064
- ISSN:
-
0028-3908
- URN:
-
uuid:f80a2f5f-8b8c-4fc3-a631-f13a6da1a6e5
- Source identifiers:
-
112359
- Local pid:
- pubs:112359
- Copyright date:
- 1994
Journal article
Tryptophan depletion in normal volunteers produces selective impairments in learning and memory.
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