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Journal article

Potent triple helix stabilization by 5',3'-modified triplex-forming oligonucleotides.

Abstract:

Anthraquinone and pyrene analogues attached to the 3' and/or 5' termini of triplex-forming oligonucleotides (TFOs) by various linkers increased the stability of parallel triple helices. The modifications are simple to synthesize and can be introduced during standard solid-phase oligonucleotide synthesis. Potent triplex stability was achieved by using doubly modified TFOs, which in the most favourable cases gave an increase in melting temperature of 30 degrees C over the unmodified counterpart...

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Publication status:
Published

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Publisher copy:
10.1002/cbic.200900232

Authors


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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
Journal:
Chembiochem : a European journal of chemical biology More from this journal
Volume:
10
Issue:
11
Pages:
1839-1851
Publication date:
2009-07-01
DOI:
EISSN:
1439-7633
ISSN:
1439-4227
Language:
English
Keywords:
Pubs id:
pubs:400008
UUID:
uuid:f801b9ee-9a4e-489e-a980-71f340a0fd28
Local pid:
pubs:400008
Source identifiers:
400008
Deposit date:
2013-11-16

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