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Transfer of type II collagen-induced arthritis from DBA/1 to severe combined immunodeficiency mice can be prevented by blockade of Mac-1.

Abstract:

Collagen-induced arthritis in susceptible mice is widely accepted as an experimental model for human rheumatoid arthritis (RA). We have investigated the role of the Mac-1 integrin beta 2 in the development and maintenance of arthritis by means of in vivo administration of 5C6 monoclonal antibody (mAb) to block this receptor. Injection of a single dose of 5C6 mAb (0.5 mg, intraperitoneally) prior to the expected onset of collagen-induced arthritis in DBA/1 mice diminished the severity of subse...

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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Author
Journal:
Immunology More from this journal
Volume:
88
Issue:
2
Pages:
315-321
Publication date:
1996-06-01
DOI:
EISSN:
1365-2567
ISSN:
0019-2805
Language:
English
Keywords:
Pubs id:
pubs:377348
UUID:
uuid:f7ff3d05-2de8-470a-9e81-e377bae10ad8
Local pid:
pubs:377348
Source identifiers:
377348
Deposit date:
2013-11-16

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