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Mouse glucocorticoid-induced tumor necrosis factor receptor ligand is costimulatory for T cells.

Abstract:

Recently, agonist antibodies to glucocorticoid-induced tumor necrosis factor receptor (GITR) (tumor necrosis factor receptor superfamily 18) have been shown to neutralize the suppressive activity of CD4+CD25+ regulatory T cells. It was anticipated that this would be the role of the physiological ligand. We have identified and expressed the gene for mouse GITR ligand and have confirmed that its interaction with GITR reverses suppression by CD4+CD25+ T cells. It also, however, provides a costim...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.2334901100

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
Journal:
Proceedings of the National Academy of Sciences of the United States of America More from this journal
Volume:
100
Issue:
25
Pages:
15059-15064
Publication date:
2003-12-01
DOI:
EISSN:
1091-6490
ISSN:
0027-8424

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