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Intra-operative recordings of local field potentials can help localize the subthalamic nucleus in Parkinson's disease surgery.

Abstract:

Deep brain stimulation (DBS) of the subthalamic nucleus (STN) can be a highly effective treatment for Parkinson's disease (PD). However, therapeutic efficacy is limited by difficulties in consistently and correctly targeting this nucleus. Increasing evidence suggests that there is abnormal synchronization of beta frequency band activity (approximately 20 Hz) in the STN of PD patients, as reflected in the oscillatory nature of the local field potential (LFP). We hypothesized that an increase i...

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Publication status:
Published

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Journal:
Experimental neurology More from this journal
Volume:
198
Issue:
1
Pages:
214-221
Publication date:
2006-03-01
DOI:
EISSN:
1090-2430
ISSN:
0014-4886
Language:
English
Keywords:
Pubs id:
pubs:122455
UUID:
uuid:f7f9c09e-ff15-46e7-b8fe-2a9d4b517410
Local pid:
pubs:122455
Source identifiers:
122455
Deposit date:
2013-02-20

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