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Analysis of B-cell immune tolerance induction using transgenic mice.

Abstract:

Over the past 15 yr, the use of transgenic mice has led to significant advances in our understanding of immunological tolerance. In a normal repertoire the number of B cells with a single antigen receptor specificity is very small, making the study of their fate difficult. In contrast, animals that carry transgenes encoding rearranged immunoglobulin genes generate large numbers of B cells that, by the process of allelic exclusion, have an identical specificity. Exploitation of this effect has...

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Publisher copy:
10.1385/1-59259-796-3:239

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
CCMP
Role:
Author
Journal:
Methods in molecular biology (Clifton, N.J.) More from this journal
Volume:
271
Pages:
239-260
Publication date:
2004-01-01
DOI:
EISSN:
1940-6029
ISSN:
1064-3745
Language:
English
Keywords:
Pubs id:
pubs:26670
UUID:
uuid:f7f62a19-adae-488e-9f78-24c9ed2b38a6
Local pid:
pubs:26670
Source identifiers:
26670
Deposit date:
2012-12-19

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