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Resistance to malaria through structural variation of red blood cell invasion receptors

Abstract:

Plasmodium falciparum invades erythrocytes via interactions with proteins on the host cell surface. By analyzing genome sequence data from human populations, including 1269 African individuals, we identify a diverse array of large copy number variants affecting the erythrocyte invasion receptor genes GYPA and GYPB. We find that a nearby association with severe malaria is explained by a complex structural rearrangement that involves the loss of GYPB and gain of two hybrid genes, each with a GY...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1126/science.aam6393

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
More from this funder
Name:
Wellcome Trust
Grant:
WT077383/Z/05/Z
Career Development Fellowship (097364/Z/11/Z
Funding agency for:
Spencer, C
More from this funder
Name:
Medical Research Council
Grant:
G0600230
G0600718
MR/M006212/1
More from this funder
Name:
Bill and Melinda Gates Foundation
Publisher:
American Association for the Advancement of Science
Journal:
Science More from this journal
Volume:
356
Issue:
6343
Article number:
eaam6393
Publication date:
2017-06-16
Acceptance date:
2017-05-08
DOI:
EISSN:
1095-920
ISSN:
0036-8075
Pubs id:
pubs:693871
UUID:
uuid:f7f57748-c702-4b7c-bad1-ec53e0508651
Local pid:
pubs:693871
Source identifiers:
693871
Deposit date:
2017-05-09

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