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HLA , CTLA-4 and PTPN22 : the shared genetic master-key to autoimmunity?

Abstract:

Several genetic loci appear to be involved in susceptibility to autoimmune disease. Some loci are disease specific, whereas others appear to exert a general effect on the autoimmune disease process. Despite a large number of studies of many different diseases, consistent associations with multiple autoimmune disorders have been restricted to three gene regions: the human leukocyte antigen (HLA) class II region on chromosome 6p21, the gene encoding cytotoxic T lymphocyte-associated 4 (CTLA-4) ...

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Publisher copy:
10.1017/S1462399405009981

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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, OCDEM, Biomedical Research Centre
Journal:
Expert reviews in molecular medicine
Volume:
7
Issue:
23
Pages:
1-15
Publication date:
2005-10-05
DOI:
EISSN:
1462-3994
ISSN:
1462-3994
URN:
uuid:f7eee9e9-727f-4114-b776-1282b58c5171
Source identifiers:
175994
Local pid:
pubs:175994

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