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Identification of an isomer impurity in piperaquine drug substance.

Abstract:

A significant contaminant of the antimalarial drug piperaquine (1,3-bis-[4-(7-chloroquinolyl-4)-piperazinyl-1]propane) has been identified using liquid chromatography-mass spectrometry (LC-MS) and 2D NMR spectroscopy (1H-1H COSY, 1H-13C HSQC, 1H-13C HMBC). The impurity was identified as the positional isomer 1-[(5-chloroquinolin-4)-piperazinyl]-3-[(7-chloroquinolin-4)-piperazinyl]propane. The impurity is formed because of contamination of batches of 4,7-dichloroquinoline (a precursor in the s...

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Publication status:
Published

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Journal:
Journal of chromatography. A More from this journal
Volume:
1135
Issue:
2
Pages:
166-169
Publication date:
2006-12-01
DOI:
EISSN:
1873-3778
ISSN:
0021-9673
Language:
English
Keywords:
Pubs id:
pubs:8806
UUID:
uuid:f7e59c98-9ddb-4a5c-8cf5-20a30ee30bef
Local pid:
pubs:8806
Source identifiers:
8806
Deposit date:
2012-12-19

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