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Journal article

Mutation analysis of hypoxia-inducible factors HIF1A and HIF2A in renal cell carcinoma.

Abstract:

BACKGROUND: Inactivation of the Von Hippel-Lindau (VHL) tumour suppressor gene leading to overexpression of hypoxia-inducible transcription factors (HIF)-1alpha and -2alpha is a critical event in the pathogenesis of most clear cell renal cell carcinomas (RCC). HIF-1alpha and HIF-2alpha share significant homology and regulate overlapping repertoires of hypoxia-inducible target genes but may have differing effects on RCC cell growth. Loss of HIF-1alpha expression has been described in RCC cell...

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Publication status:
Published

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Journal:
Anticancer research
Volume:
29
Issue:
11
Pages:
4337-4343
Publication date:
2009-11-05
EISSN:
1791-7530
ISSN:
0250-7005
URN:
uuid:f7e021c8-a316-4247-bbdc-88e70478e98c
Source identifiers:
45965
Local pid:
pubs:45965

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