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LET dependence of the yield of single-, double-strand breaks and base lesions in fully hydrated plasmid DNA films by 4He(2+) ion irradiation.

Abstract:

PURPOSE: To characterize the complexity of DNA damage through determination of the yields of single (SSB) and double strand breaks (DSB), base lesions and clustered damage sites induced in fully hydrated plasmid DNA by direct radiation effects as a function of the ionizing density of the radiation using 4He(2+) ion irradiation with linear energy-transfer (LET) values in the range 19 to 148 keV/microm. MATERIALS AND METHODS: Hydrated plasmid DNA (pUC18) containing 34.5 water molecules/nucleoti...

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Publication status:
Published

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Publisher copy:
10.1080/09553000701616072

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
Journal:
International journal of radiation biology More from this journal
Volume:
84
Issue:
1
Pages:
23-33
Publication date:
2008-01-01
DOI:
EISSN:
1362-3095
ISSN:
0955-3002
Language:
English
Keywords:
Pubs id:
pubs:311003
UUID:
uuid:f7dd9ba9-4eae-46f3-b7f9-1ea9de8f80f1
Local pid:
pubs:311003
Source identifiers:
311003
Deposit date:
2012-12-19

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