- Abstract:
-
AIMS: The level of inhibition of the human Ether-à-go-go-related gene (hERG) channel is one of the earliest preclinical markers used to predict the risk of a compound causing Torsade-de-Pointes (TdP) arrhythmias. While avoiding the use of drugs with maximum therapeutic concentrations within 30-fold of their hERG inhibitory concentration 50% (IC(50)) values has been suggested, there are drugs that are exceptions to this rule: hERG inhibitors that do not cause TdP, and drugs that can cause TdP...
Expand abstract - Publication status:
- Published
- Files:
-
-
(pdf, 339.9KB)
-
- Publisher copy:
- 10.1093/cvr/cvr044
-
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- Journal:
- Cardiovascular research
- Volume:
- 91
- Issue:
- 1
- Pages:
- 53-61
- Publication date:
- 2011-07-05
- DOI:
- EISSN:
-
1755-3245
- ISSN:
-
0008-6363
- URN:
-
uuid:f7c85a24-cb5a-496e-9dc4-717c1a9d93f3
- Source identifiers:
-
237657
- Local pid:
- pubs:237657
- Language:
- English
- Keywords:
- Copyright date:
- 2011
Journal article
Simulation of multiple ion channel block provides improved early prediction of compounds' clinical torsadogenic risk.
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