Hypoxia and oxidative stress in breast cancer. Hypoxia and tumourigenesis.

Journal article

The microenvironmental hypoxia that arises as a consequence of the development of a solid tumour also acts to promote tumour growth. Hypoxia induces the expression of key components of the angiogenic and apoptotic signalling cascades, the glycolytic pathway and various cell-cycle control proteins. At the cellular level it mediates the infiltration and accumulation of tumour-associated macrophages within avascular tumour regions. Complex interactions between tumour cell and macrophage hypoxia-regulated gene products and their associated pathways form the basis for the hypoxic promotion of tumourigenesis and malignant progression.

Authors: Knowles, H; Harris, A

• Publication status: Published
• Journal: Breast cancer research : BCR
• Volume: 3
• Issue: 5
• Pages: 318-322
• Publication date: 2001-01-01
• DOI: 10.1186/bcr314
• EISSN: 1465-542X
• ISSN: 1465-5411
• Language: English
• Keywords: Cell Transformation, Neoplastic; Breast Neoplasms; Neovascularization, Pathologic; Oxidative Stress; Humans; Breast; Female; Apoptosis; Cell Hypoxia