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Hypoxia and oxidative stress in breast cancer. Hypoxia and tumourigenesis.

Abstract:

The microenvironmental hypoxia that arises as a consequence of the development of a solid tumour also acts to promote tumour growth. Hypoxia induces the expression of key components of the angiogenic and apoptotic signalling cascades, the glycolytic pathway and various cell-cycle control proteins. At the cellular level it mediates the infiltration and accumulation of tumour-associated macrophages within avascular tumour regions. Complex interactions between tumour cell and macrophage hypoxia-...

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Publication status:
Published

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Publisher copy:
10.1186/bcr314
Journal:
Breast cancer research : BCR More from this journal
Volume:
3
Issue:
5
Pages:
318-322
Publication date:
2001-01-01
DOI:
EISSN:
1465-542X
ISSN:
1465-5411
Language:
English
Keywords:
Pubs id:
pubs:108832
UUID:
uuid:f7bcbd10-010d-4c0f-91c2-03ce1dc27bae
Local pid:
pubs:108832
Source identifiers:
108832
Deposit date:
2012-12-19

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